SIDE EFFECTS
An increased risk of the following serious adverse reactions
has been associated with the use of oral contraceptives
(See WARNINGS Section).
Thrombophlebitis and venous thrombosis with or without
embolism
Arterial thromboembolism
Pulmonary embolism
Myocardial infarction
Cerebral hemorrhage
Cerebral thrombosis
Hypertension
Gallbladder disease
Hepatic adenomas or benign liver tumors
The following adverse reactions have been reported in patients
receiving oral contraceptives and are believed to be drug-related:
Nausea
Vomiting
Gastrointestinal symptoms (such as abdominal cramps and
bloating)
Breakthrough bleeding
Spotting
Change in menstrual flow
Amenorrhea
Temporary infertility after discontinuation of treatment
Edema
Melasma which may persist
Breast changes: tenderness, enlargement, secretion
Change in weight (increase or decrease)
Change in cervical erosion and secretion
Diminution in lactation when given immediately postpartum
Cholestatic jaundice
Migraine
Rash (allergic)
Mental depression
Reduced tolerance to carbohydrates
Vaginal candidiasis
Change in corneal curvature (steepening)
Intolerance to contact lenses
The following adverse reactions have been reported in users
of oral contraceptives and the association has been neither
confirmed nor refuted:
Pre-menstrual syndrome
Cataracts
Changes in appetite
Cystitis-like syndrome
Headache
Nervousness
Dizziness
Hirsutism
Loss of scalp hair
Erythema multiforme
Erythema nodosum
Hemorrhagic eruption
Vaginitis
Porphyria
Impaired renal function
Hemolytic uremic syndrome
Acne
Changes in libido
Colitis
Budd-Chiari Syndrome
DRUG INTERACTIONS
Reduced efficacy and increased incidence of breakthrough
bleeding and menstrual irregularities have been associated
with concomitant use of rifampin. A similar association,
though less marked, has been suggested with barbiturates,
phenylbutazone, phenytoin sodium, carbamazepine, and possibly
with griseofulvin, ampicillin and tetracyclines.
Certain drugs may interact with birth control pills to
make them less effective in preventing pregnancy or cause
an increase in breakthrough bleeding. Such drugs include
rifampin, drugs used for epilepsy such as barbiturates
(for example, phenobarbital), anticonvulsants such as
carbamazepine (Tegretol is one brand of this drug), phenytoin
(Dilantin is one brand of this drug), phenylbutazone (Butazolidin
is one brand) and possibly certain antibiotics. You may
need to use additional contraception when you take drugs
which can make oral contraceptives less effective.
See also PRECAUTIONS, WARNINGS sections
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