OVERDOSE
Single oral doses of 3 g/kg benazepril were associated
with significant lethality in mice. Rats however, tolerated
single oral doses of up to 6 g/kg. Reduced activity was
seen at 1 g/kg in mice and at 5 g/kg in rats. Human overdoses
of benazepril have not been reported, but the most common
manifestation of human benazepril overdosage is likely
to be hypotension.
Laboratory determinations of serum levels of benazepril
and its metabolites are not widely available, and such
determinations have, in any event, no established role
in the management of benazepril overdose.
No data are available to suggest physiological maneuvers
(e.g., maneuvers to change the pH of the urine) that might
accelerate elimination of benazepril and its metabolites.
Benazepril is only slightly dialyzable, but dialysis might
be considered in overdosed patients with severely impaired
renal function (see WARNINGS).
Angiotensin II could presumably serve as a specific antagonist-antidote
in the setting of benazepril overdose, but angiotensin
II is essentially unavailable outside of scattered research
facilities. Because the hypotensive effect of benazepril
is achieved through vasodilation and effective hypovolemia,
it is reasonable to treat benazepril overdose by infusion
of normal saline solution.
CONTRAINDICATIONS
Benazepril HCl is contraindicated in patients who are hypersensitive
to this product or to any other ACE inhibitor.
| |
