SIDE EFFECTS
The following additional adverse reactions have been
reported with estrogen therapy (see WARNINGS regarding
induction of neoplasia, adverse effects on the fetus,
increased incidence of gallbladder disease, cardiovascular
disease, elevated blood pressure, and hypercalcemia).
Genitourinary System: Changes
in vaginal bleeding pattern and abnormal withdrawal bleeding
or flow; breakthrough bleeding, spotting; increase in
size of uterine leiomyomata; vaginal candidiasis; change
in amount of cervical secretion.
Breasts: Tenderness, enlargement.
Gastrointestinal: Nausea; vomiting;
abdominal cramps; bloating; cholestatic jaundice; increased
incidence of gallbladder disease.
Skin: Chloasma or melasma which
may persist when drug is discontinued; erythema multiforme;
erythema nodosum; hemorrhagic eruption; loss of scalp
hair; hirsutism.
Eyes: Steepening of corneal
curvature; intolerance to contact lenses.
Central Nervous System: Headache;
migraine; dizziness; mental depression; chorea.
Miscellaneous: Increase or
decrease in weight; reduced carbohydrate tolerance; aggravation
of porphyria; edema; changes in libido.
DRUG INTERACTIONS
See PRECAUTIONS.
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