OVERDOSE
There has been one reported case of overdosage with fluconazole.
A 42-year-old patient infected with human immunodeficiency
virus developed hallucinations and exhibited paranoid
behavior after reportedly ingesting 8200 mg of fluconazole.
The patient was admitted to the hospital, and his condition
resolved within 48 hours.
In the event of overdose, symptomatic treatment (with
supportive measures and gastric lavage if clinically indicated)
should be instituted.
Fluconazole is largely excreted in urine. A three hour
hemodialysis session decreases plasma levels by approximately
50%.
In mice and rats receiving very high doses of fluconazole,
clinical effects in both species included decreased motility
and respiration, ptosis, lacrimation, salivation, urinary
incontinence, loss of righting reflex and cyanosis; death
was sometimes preceded by clonic convulsions.
CONTRAINDICATIONS
Fluconazole is contraindicated in patients who have shown
hypersensitivity to fluconazole or to any of its excipients.
There is no information regarding cross hypersensitivity
between fluconazole and other azole antifungal agents.
Caution should be used in prescribing fluconazole to patients
with hypersensitivity to other azoles.
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