OVERDOSE
A 27-month-old child who ingested 5 to 7 tablets of DETROL
2 mg was treated with a suspension of activated charcoal
and was hospitalized overnight with symptoms of dry mouth.
The child fully recovered.
Management of
OVERDOSE
Overdosage with DETROL can potentially result in severe
central anticholinergic effects and should be treated
accordingly.
ECC monitoring is recommended in the event of overdosage.
In dogs, changes in the QT interval (slight prolongation
of 10% to 20%) were observed at a suprapharmacologic dose
of 4.5 mg/kg, which is about 68 times higher than the
recommended human dose. In clinical trials of normal volunteers
and patients, QT interval prolongation was not observed
at doses up to 4 mg twice daily of tolterodine (higher
doses were not evaluated).
CONTRAINDICATIONS
DETROL Tablets are contraindicated in patients with urinary
retention, gastric retention, or uncontrolled narrow-angle
glaucoma. DETROL is also contraindicated in patients who
have demonstrated hypersensitivity to the drug or its
ingredients.
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