DEPO-PROVERA Contraceptive Injection contains medroxyprogesterone
acetate, a derivative of progesterone, as its active ingredient.
Medroxyprogesterone acetate is active by the parenteral
and oral routes of administration. It is a white to off-white,
odorless crystalline powder that is stable in air and
that melts between 200°C and 210°C. It is freely
soluble in chloroform, soluble in acetone and dioxane,
sparingly soluble in alcohol and methanol, slightly soluble
in ether, and insoluble in water.
The chemical name for medroxyprogesterone acetate is
pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6(alpha))-.
DEPO-PROVERA Contraceptive Injection for intramuscular (IM)
injection is available in vials and prefilled syringes,
each containing 1 mL of medroxyprogesterone acetate sterile
aqueous suspension 150 mg/mL.
Each mL contains:
Medroxyprogesterone acetate
150 mg
Polyethylene glycol 3350
28.9 mg
Polysorbate 80
2.41 mg
Sodium chloride
8.68 mg
Methylparaben
1.37 mg
Propylparaben
0.150 mg
Water for injection
qs
When necessary, pH is adjusted with sodium hydroxide or
hydrochloric acid, or both.
