OVERDOSE
Significant lethality was observed in mice and rats after
oral administration of 1000 mg/kg and 2000 mg/kg, respectively,
about 44 and 170 times the maximum recommended human dose
on a mg/m2 basis.
Limited data are available in regard to overdosage in
humans. The most likely manifestation of overdosage would
be hypotension and tachycardia; bradycardia could occur
from parasympathetic (vagal) stimulation. If symptomatic
hypotension should occur, supportive treatment should
be instituted.
Neither losartan nor its active metabolite can be removed
by hemodialysis.
CONTRAINDICATIONS
Losartan potassium is contraindicated in patients who
are hypersensitive to any component of this product.
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