SIDE EFFECTS
Potential Adverse Reactions To Warfarin Sodium
May Include
Fatal or nonfatal hemorrhage from any tissue
or organ: This is a consequence of the anticoagulant
effect. The signs, symptoms, and severity will vary according
to the location and degree or extent of the bleeding.
Hemorrhagic complications may present as paralysis; paresthesia;
headache, chest, abdomen, joint, muscule, or other pain;
dizziness, shortness of breath, difficult breathing or
swallowing; unexplained swelling; weakness; hypotension;
or unexplained shock. Therefore, the possibility of hemorrhage
should be considered in evaluating the condition of any
anticoagulated patient with complaints which do not indicate
an obvious diagnosis. Bleeding during anticoagulant therapy
does not always correlate with PT/INR . (See OVERDOSAGE,
Treatment.)
Bleeding: which occurs when
the PT/INR is within the therapeutic range warrants diagnostic
investigation since it may unmask a previously unsuspected
lesion, e.g., tumor, ulcer, etc.
Necrosis of skin and other tissues. (See
WARNINGS.)
Adverse reactions reported infrequently include:
Hypersensitivity reactions, systemic cholesterol microembolization,
purple toes syndrome, vasculitis, hepatitis, cholestatic
hepatic injury, jaundice, elevated liver enzymes, fever,
dermatitis, including bullous eroptions, urticaria, abdominal
pain including cramping, asthenia, nausea, vomiting, diarrhea,
headache, pruritis, alopecia, and paresthesia.
Rare events of tracheal or tracheobronchial calcification
have been reported in association with long-term warfarin
sodium therapy. The clinical significance of this event
is unknown.
Priapism has been associated with anticoagulant administration,
however, a causal relationship has not been established.
DRUG INTERACTIONS
No information provided.
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