DESCRIPTION
Crystalline warfarin sodium, is an anticoagulant which
acts by inhibiting vitamin K-dependent coagulation factors.
Chemically, it is 3- (a-acetonylbenzyl) -4 -hydroxycoumarin
and is a racemic mixture of the R and S enantiomers. Crystalline
warfarin sodium is an isopropanol clathrate. The crystallization
of warfarin sodium virtually eliminates trace impurities
present in amorphous warfarin sodium. Its empirical formula
isC19H15NaO4.
Crystalline warfarin sodium occurs as a white, odorless,
crystalline powder, is discolored by light and is very
soluble in water; freely soluble in alcohol; very slightly
soluble in chloroform and in ether.
Coumadin Tablets
Coumadin Tablets for Oral Use Also Contain:
All strengths: Lactose, starch and magnesium
stearate; 1 mg: D&C Red 6; 2 mg: FD&C Blue 2 and
FD&C Red 40; 2-1/2 mg: FD&C Blue 1 and D&C
Yellow 10; 4 mg: FD&C Blue 1 Lake; 5 mg: FD&C
Yellow 6; 7-1/2 mg: D&C Yellow 10 and FD&C Yellow
6; 10 mg: Dye Free.
Coumadin for Injection
Coumadin for Injection is supplied as a sterile, lyophilized
powder, which, after reconstitution with 2.7 ml sterile
Water for Injection, contains: Warfarin sodium: 2 mg/ml;
Sodium Phosphate, Dibasic, Heptahydrate: 4.98 mg/ml; Sodium
Phosphate, Monobasic, Monohydrate: 0.194 mg/ml Sodium
Chloride: 0.1 mg/ml; Mannitol: 38.0 mg/ml; Sodium Hydroxide,
as needed for pH adjustment to: 8.1 to 8.3.
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