DESCRIPTION
Carvedilol is a nonselective b- adrenergic blocking agent
with a1-blocking activity. It is (±)-1-(Carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)
ethyl] aminol-2-propanol. It is a racemic mixture.
Tablets for Oral Administration
Coreg (carvedilol) is a white, oval, film-coated tablet
containing 3.125 mg, 6.25 mg, 12.5 mg or 25 mg of carvedilol.
The 6.25 mg, 12.5 mg and 25 mg tablets are Tiltab®
tablets. Inactive ingredients consist of colloidal silicon
dioxide, crospovidone, hydroxypropyl methylcellulose,
lactose, magnesium stearate, polyethylene glycol, polysorbate
80, povidone, sucrose and titanium dioxide.
Carvedilol is a white to off-white powder with a molecular
weight of 406.5 and a molecular formula ofC24H26N2O4.
It is freely soluble in dimethylsulfoxide; soluble in
methylene chloride and methanol; sparingly soluble in
95% ethanol and isopropanol; slightly soluble in ethyl
ether; and practically insoluble in water, gastric fluid
(simulated, TS, pH1.1) and intestinal fluid (simulated,
TS without pancreatin, pH 7.5).
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