OVERDOSE
COMBIVIR:There is no known antidote
for COMBIVIR.
Lamivudine: One case of an adult ingesting 6 grams of
lamivudine was reported; there were no clinical signs
or symptoms noted and hematologic tests remained normal.
It is not known whether lamivudine can be removed by peritoneal
dialysis or hemodialysis.
Zidovudine: Acute overdoses of zidovudine
have been reported in pediatric patients and adults. These
involved exposures up to 50 grams. The only consistent
findings were nausea and vomiting. Other reported occurrences
included headache, dizziness, drowsiness, lethargy, confusion,
and one report of a grand mal seizure. Hematologic changes
were transient. All patients recovered. Hemodialysis and
peritoneal dialysis appear to have a negligible effect
on the removal of zidovudine while elimination of its
primary metabolite, GZDV, is enhanced.
CONTRAINDICATIONS
COMBIVIR Tablets are contraindicated in patients with
previously demonstrated clinically significant hypersensitivity
to any of the components of the product.
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