DESCRIPTION
CLORPRES™ is a combination of clonidine hydrochloride
(a centrally acting antihypertensive agent) and chlorthalidone
(a diuretic). CLORPRES™ is available as tablets
for oral administration in three dosage strengths: 0.1
mg/15 mg, 0.2 mg/15 mg and 0.3 mg/15 mg of clonidine hydrochloride/chlorthalidone,
respectively.
The inactive ingredients are ammonium chloride, colloidal
silicon dioxide, croscarmellose sodium (Type A), magnesium
stearate, microcrystalline cellulose, sodium lauryl sulfate,
D&C yellow #10.
Clonidine Hydrochloride: Clonidine hydrochloride
is an imidazoline derivative and exists as a mesomeric
compound. The chemical name is 2-[(2,6-dichlorophenyl)imino]imidazoline
monohydrochloride.
Clonidine hydrochloride is an odorless, bitter, white
crystalline substance soluble in water and alcohol.
Chlorthalidone: Chlorthalidone is a
monosulfamyl diuretic that differs chemically from thiazide
diuretics in that a double ring system is incorporated
in its structure. It is 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)
benzenesulfonamide.
Chlorthalidone is practically insoluble in water, in
ether and in chloroform; soluble in methanol; slightly
soluble in alcohol.
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