SIDE EFFECTS
Adverse reactions in decreasing order of severity are:
bone marrow depression, with aplastic anemia, with agranulocytosis
or with thrombocytopenia may occur in patients receiving
long-term therapy. Peripheral neuritis, purpura, myopathy,
loss of hair, and reversible azoospermia have also been
reported.
Vomiting, diarrhea, and nausea may occur with colchicine
therapy, especially when maximal doses are necessary for
a therapeutic effect. To avoid more serious toxicity,
the drug should be discontinued when these symptoms appear,
regardless of whether or not joint pain has been relieved.
Dermatoses have been reported. Hypersensitivity reactions
may occur infrequently.
DRUG INTERACTIONS
Colchicine is inhibited by acidifying agents. The action
of colchicine is potentiated by alkalinizing agents.
Colchicine may increase sensitivity to the CNS depressants.
Response to sympathomimetic agents’may be enhanced
by colchicine.
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