OVERDOSE
Oral
In the event of acute overdosage, the stomach should
be emptied by inducing vomiting or by gastric lavage.
The patient should be carefully observed and given supportive
treatment. Adequate hydration must be maintained. Only
a small amount of ciprofloxacin (<10%) is removed from
the body after hemodialysis of peritoneal dialysis.
In mice, rats, rabbits and dogs, significant toxicity
including tonic/clonic convulsions was observed at intravenous
doses of ciprofloxacin between 125 and 300 mg/kg.
Single doses of ciprofloxacin were relatively non-toxic
via the oral route of administration in mice, rats, and
dogs. No deaths occurred within a 14-day post treatment
observation period at the highest oral doses tested; up
to 5000 mg/kg in either rodent species, or up to 2500
mg/kg in the dog. Clinical signs observed included hypoactivity
and cyanosis in both rodent species and severe vomiting
in dogs. In rabbits, significant mortality was seen at
doses of ciprofloxacin > 2500 mg/kg. Mortality was
delayed in these animals, occurring 10-14 days after dosing.
I.V.
In the event of acute overdosage, the patient should
be carefully observed and given supportive treatment.
Adequate hydration must be maintained. Only a small amount
of ciprofloxacin (10%) is removed from the body after
hemodialysis or peritoneal dialysis.
In mice, rats, rabbits and dogs, significant toxicity
including tonic/clonic convulsions was observed at intravenous
doses of ciprofloxacin between 125 and 300 mg/kg.
CONTRAINDICATIONS
Ciprofloxacin is contraindicated in persons with a history
of hypersensitivity to ciprofloxacin or any member of
the quinolone class of antimicrobial agents.
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