SIDE EFFECTS
The following adverse reactions (incidences) were reported
in 2% of the patients in clinical studies for CILOXAN
Ophthalmic Ointment: discomfort, keratopathy. Other reactions
associated with ciprofloxacin therapy occurring in less
than 1% of patients included allergic reactions, blurred
vision, corneal staining, decreased visual acuity, dry
eye, edema, epitheliopathy, eye pain, foreign body sensation,
hyperemia, irritation, keratoconjunctivitis, keratopathy,
lid erythema, lid margin hyperemia, photophobia, pruritus,
and tearing.
Systemic adverse reactions related to ciprofloxacin therapy
occurred at an incidence below 1% and included dermatitis,
nausea and taste perversion.
DRUG INTERACTIONS
Specific drug interaction studies have not been conducted
with ophthalmic ciprofloxacin. However, the systemic administration
of some quinolones has been shown to elevate plasma concentrations
of theophylline, interfere with the metabolism of caffeine,
enhance the effects of the oral anticoagulant, warfarin,
and its derivatives, and has been associated with transient
elevations in serum creatinine in patients receiving cyclosporine
concomitantly.
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