DESCRIPTION
Cefprozil is a semi-synthetic broad-spectrum cephalosporin
antibiotic.
Cefprozil is a cis and trans isomeric mixture (³
90% cis). The chemical name for the monohydrate is (6R,7R)-7-((R)-2-amino-2-(p-hydroxy-phenyl)acetamido)-8-oxo-3-propenyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
acid monohydrate.
Cefprozil is a white to yellowish powder with a molecular
formula for the monohydrate of C18H19N3O5S·H2O
and a molecular weight of 407.45.
Cefzil tablets contain cefprozil equivalent to 250 mg
or 500 mg of anhydrous cefprozil. In addition, each tablet
contains the following inactive ingredients: cellulose,
hydroxypropylmethylcellulose, magnesium stearate, methylcellulose,
simethicone, sodium starch glycolate, polyethylene glycol,
polysorbate 80, sorbic acid and titanium dioxide. The
250 mg tablets also contain FD&C yellow No. 6.
Cefzil for oral suspension contains cefprozil equivalent
to 125 mg or 250 mg anhydrous cefprozil per 5 ml constituted
suspension. In addition, the oral suspension contains
the following inactive ingredients: aspartame, cellulose,
citric acid, colloidal silicone dioxide, FD&C red
No. 3, flavors (natural and artificial), glycine, polysorbate
80, simethicone, sodium benzoate, sodium carboxymethylcellulose,
sodium chloride, and sucrose.
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