DESCRIPTION
Ceftin tablets and Ceftin for oral suspension contain
cefuroximine as cefuroximine axetil. Cefuroxime axetil
is a semisynthetic, broad-spectrum cephalosporin antibiotic
for oral administration.
Chemically, cefuroxime axetil, the 1-(acetyloxy) ethyl
ester of cefuroxime, is (RS)-1-hydroxyethyl (6R,7R)-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,
72-(Z)-(O-methyl-oxime),1 -acetate 3-carbamate. Its molecular
formula is C20H22N4O10S, and it has a molecular weight
of 510.48.
Cefuroxime axetil is in the amorphous form.
Ceftin tablets are film-coated and contain the equivalent
of 125, 250, or 500 mg of cefuroxime as cefuroxime axetil.
Ceftin tablets contain the inactive ingredients colloidal
silicon dioxide, croscarmellose sodium, FD&C blue
no. 1 (250-and 500-mg tablets only), hydrogenated vegetable
oil, hydroxypropyl methylcellulose, methylparaben, microcrystalline
cellulose, propylene glycol, propylparaben, sodium benzoate
(125-mg tablets only), sodium lauryl sulfate, and titanium
dioxide.
Ceftin for oral suspension, when reconstituted with water,
provides the equivalent of 125 mg or 250 mg of cefuroxime
(as cefuroxime axetil) per 5 ml of suspension. Ceftin powder
for oral suspension contains the inactive ingredients povidone
K30, stearic acid, sucrose, and tutti-frutti flavoring.
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