DESCRIPTION
Doxazosin mesylate is a quinazoline compound that is
a selective inhibitor of the alpha1 subtype of alpha adrenergic
receptors. The chemical name of doxazosin mesylate is
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)
piperazine methanesulfonate. The empirical formula for
doxazosin mesylate is C23H25N5O5•CH4O3S and the
molecular weight is 547.6.
Cardura is freely soluble in dimethylsulfoxide, soluble
in dimethylformamide, slightly soluble in methanol, ethanol,
and water (0.8% at 25°C), and very slightly soluble
in acetone and methylene chloride. Doxazosin mesylate
is available as colored tablets for oral use and contains
1 mg (white), 2 mg (yellow), 4 mg (orange) and 8 mg (green)
of doxazosin as the free base.
The inactive ingredients for all tablets are: microcrystalline
cellulose, lactose, sodium starch glycolate, magnesium
stearate and sodium lauryl sulfate. The 2 mg tablet contains
FD&C yellow 10 and FD&C yellow 6; the 4 mg tablet
contains FD&C yellow 6; the 8 mg tablet contains FD&C
blue 10 and FD&C yellow 10
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