OVERDOSE
Overdoses of nizatidine have been reported rarely. The
following is provided to serve as a guide should such
an overdose be encountered.
Signs and Symptoms: There is little
clinical experience with overdosage of nizatidine in humans.
Test animals that received large doses of nizatidine have
exhibited cholinergic-type effects, including lacrimation,
salivation, emesis, miosis, and diarrhea. Single oral
doses of 800 mg/kg in dogs and of 1200 mg/kg in monkeys
were not lethal. Intravenous median lethal doses in the
rat and mouse were 301 mg/kg and 232 mg/kg respectively.
Treatment: To obtain up-to-date information
about the treatment of overdose, a good resource is your
certified Regional Poison Control Center. In managing
overdosage, consider the possibility of multiple drug
overdoses, interaction among drugs, and unusual drug kinetics
in your patient.
If overdosage occurs, use of activated charcoal, emesis,
or lavage should be considered along with clinical monitoring
and supportive therapy. The ability of hemodialysis to
remove nizatidine from the body has not been conclusively
demonstrated; however, due to its large volume of distribution,
nizatidine is not expected to be efficiently removed from
the body by this method.
CONTRAINDICATIONS
Nizatidine is contraindicated in patients with known hypersensitivity
to the drug. Because cross sensitivity in this class of
compounds has been observed, H2-receptor antagonists, including
nizatidine, should not be administered to patients with
a history of hypersensitivity to other H2-receptor antagonists.
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