DESCRIPTION
Augmentin is an oral antibacterial combination
consisting of the semisynthetic antibiotic amoxicillin and
the b-lactamase inhibitor, clavulanate potassium (the potassium
salt of clavulanic acid). Amoxicillin is an analog of ampicillin,
derived from the basic penicillin nucleus, 6-aminopenicillanic
acid. The amoxicillin molecular formula is C16H19N3O5S·3H2O
and the molecular weight is 419.46. Chemically, amoxicillin
is (2S, 5R, 6R)-6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid trihydrate.
Clavulanic acid is produced by the fermentation of Streptomyces
clavuligerus. It is a b-lactam structurally related to the
penicillins and possesses the ability to inactivate a wide
variety of b-lactamases by blocking the active sites of
these enzymes. Clavulanic acid is particularly active against
the clinically important plasmid mediated b-lactamases frequently
responsible for transferred drug resistance to penicillins
and cephalosporins. The clavulanate potassium molecular
formula is C8H8KNO5 and the molecular weight is 237.25.
Chemically clavulanate potassium is potassium (Z)-(2R,5R
)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate.
Each Augmentin tablet contains 0.63 mEq potassium.
Each 125 mg chewable tablet and each 5 ml of reconstituted
Augmentin 125 mg/5 ml oral suspension contains 0.16 mEq
potassium. Each 250 mg chewable tablet and each 5 ml of
reconstituted Augmentin 250 mg/5 ml oral suspension contains
0.32 mEq potassium. Each 200 mg chewable tablet and each
5 ml of reconstituted Augmentin 200 mg/5 ml oral suspension
contains 0.14 mEq potassium. Each 400 mg chewable tablet
and each 5 ml of reconstituted Augmentin 400 mg/5 ml oral
suspension contains 0.29 mEq of potassium.
Inactive Ingredients
Powder for Oral Suspension: Colloidal silicon dioxide,
flavorings (see HOW SUPPLIED), succinic acid, xanthan gum,
and one or more of the following: aspartame, hydroxypropyl
methylcellulose, mannitol, silica gel, silicon dioxide and
sodium saccharin.
Chewable Tablets: Colloidal silicon dioxide,
flavorings (see HOW SUPPLIED), magnesium stearate, mannitol
and one or more of the following: aspartame, D&C yellow
no. 10, FD&C red no. 40, glycine, sodium saccharin and
succinic acid.
(For additional information concerning aspartame see PRECAUTIONS,
Information for the Patient.)
Tablets: Colloidal silicon dioxide, hydroxypropyl
methylcellulose, magnesium stearate, microcrystalline cellulose,
polyethylene glycol, sodium starch glycolate and titanium
dioxide.
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