DESCRIPTION

Brimonidine tartrate is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. The chemical name of brimonidine tartrate is 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. It is an off-white, pale yellow to pale pink powder. In solution, brimonidine tartrate has a clear, greenish-yellow color. It has a molecular weight of 442.24 as the tartrate salt and is water soluble (34 mg/ml). The molecular formula is C₁₁H₁₀BrN₅•C₄H₆O₆. Brimonidine tartrate ophthalmic solution 0.2% is a sterile ophthalmic solution.

Each ml of Alphagan Solution contains: Active: Brimonidine tartrate 2 mg (equivalent to 1.32 mg as brimonidine free base).Preservative: Benzalkonium chloride (0.05 mg). Inactives: Polyvinyl alcohol; sodium chloride; sodium citrate; citric acid; and purified water. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH (6.3-6.5).