OVERDOSE

Acute overdosage may produce acute hypotension with other responses attributable to brain and gastrointestinal malfunction (excessive sedation, weakness, bradycardia dizziness, lightheadedness, constipation, distention, flatus diarrhea, nausea, vomiting).

In the event of overdosage symptomatic and supportive measures should be employed. When ingestion is recent, gastric lavage or emesis may reduce absorption. When ingestion has been earlier, infusions may be helpful to promote urinary excretion. Otherwise, management includes special attention to cardiac rate and output, blood volume, electrolyte imbalance, paralyticileus, urinary function and cerebral activity. Sympathomimetic drugs [e.g., norepinephrine. epinephrine, metaraminol bitartrate] may be indicated. Methyldopa is dialyzable.

The oral LD50 of methyldopa is greater than 1.5 g/kg in both the mouse and the rat.

CONTRAINDICATIONS

Methyldopa is contraindicated in patients:

- with active hepatic disease, such as acute hepatitis and active cirrhosis.
- with liver disorders previously associated with methyldopa therapy (see WARNINGS).
- with hypersensitivity to any component of this product.
- on therapy with monoamine oxidase (MAO) inhibitors.