DESCRIPTION
AGGRENOXTM is a combination antiplatelet agent
intended for oral administration. Each hard gelatin capsule
contains 200 mg dipyridamole in an extended-release form
and 25 mg aspirin, as an immediate-release sugar-coated
tablet. In addition, each capsule contains the following
inactive ingredients: acacia, aluminum stearate, colloidal
silicon dioxide, corn starch, dimethicone, hydroxypropyl
methylcellulose, hydroxypropyl methylcellulose phthalate,
lactose monohydrate, methacrylic acid copolymer, microcrystalline
cellulose, povidone, stearic acid, sucrose, talc, tartaric
acid, titanium dioxide and triacetin.
Each capsule shell contains gelatin, red iron oxide and
yellow iron oxide, titanium dioxide and water.
Dipyridamole
Dipyridamole is an antiplatelet agent chemically described
as 2,6-bis(diethanolamino)-4,8-dipiperidino- pyrimido(5,4-d)
pyrimidine (=dipyridamole).
It has the following molecular formula C24H40N8O4
with a molecular weight of 504.63.
Dipyridamole is an odorless yellow crystalline substance,
having a bitter taste. It is soluble in dilute acids,
methanol and chloroform, and is practically insoluble
in water.
Aspirin
The antiplatelet agent aspirin (acetylsalicylic acid)
is chemically known as benzoic acid, 2-(acetyloxy)-, and
has the following molecular formula C9H8O4
with a molecular weight of 180.16.
Aspirin is an odorless white needle-like crystalline or
powdery substance. When exposed to moisture, aspirin hydrolyzes
into salicylic and acetic acids, and gives off a vinegary
odor. It is highly lipid soluble and slightly soluble in
water. |
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