OVERDOSE
No deaths occurred at oral zafirlukast doses of 2000
mg/kg in mice (approximately 200 times the maximum recommended
human daily oral dose on a mg/m2 basis), 2000 mg/kg in
rats (approximately 400 times the maximum recommended
human daily oral dose on a mg/m2 basis), and 500 mg/kg
in dogs (approximately 330 times the maximum recommended
human daily oral dose on a mg/m2 basis).
There is no experience to date with zafirlukast in overdose
in humans. It is reasonable to employ the usual supportive
measures in the event of an overdose; e.g., remove unabsorbed
material from the gastrointestinal tract, employ clinical
monitoring, and institute supportive therapy, if required.
CONTRAINDICATIONS
Zafirlukast is contraindicated in patients who are hypersensitive
to zafirlukast or any of its inactive ingredients.
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