DESCRIPTION
Zafirlukast is a synthetic, selective peptide leukotriene
receptor antagonist (LTRA), with the chemical name 4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide.
The molecular weight of zafirlukast is 575.7.
The empirical formula is C31H33N306S.
Zafirlukast, a fine white to pale yellow amorphous powder,
is practically insoluble in water. It is slightly soluble
in methanol and freely soluble in tetrahydrofuran, dimethylsulfoxide,
and acetone.
Accolate is supplied as a 20 mg tablet for oral administration.
Inactive Ingredients: Film-coated tablets containing croscarmellose
sodium, lactose, magnesium stearate, microcrystalline
cellulose, povidone, hydroxypropylmethylcellulose and
titanium dioxide.
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